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KMID : 0604520120380040277
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 4 p.277 ~ p.287
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Medicinal Herbal Complex Extract with Potential for Hair Growth-Promoting Activity
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Lee Jun-Young
Lim Kyung-Ran
Jung Taek-Kyu
Lee Myung-Hee
Yoon Kyung-Sup
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Abstract
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To develop new therapeutic materials to prevent hair loss and enhance hair growth, we developed a medicinal herbal complex extract (MHCE) using 23 herbs traditionally used in oriental medicine. Medicinal Herbal complex extract was consist of Angelica gigas Nakai, Psoralea corylifolia Linne, Biota orientalis Endlicher, and Eclipta prostrata Linne, Rehmannia glutinosa Liboschitz var. purpurea Makino, Ligustrum lucidum Aiton, Polygonum multiflorum Thunberg, and Sesamum indicum Linne, Sophora angustifolia Sieboldet Zuccarini, Angelica dahurica Benthamet Hooker, and Leonurus sibiricus Linne, Salvia miltiorrhiza Bunge, Prunus persica Batsch, Commiphora molmol Engler, Chrysanthemum indicum Linne, Boswellia carterii Birdwood, Panax ginseng C. A. Meyer, Cnidium officinale Makino, Albizia julibrissin Durazzini, and Corydalis ternata Nakai that have traditionally been used for treating hair loss, preventing gray hair, anti-inflammation, and blood circulation in oriental medicine. In addition, we examined the hair growth effect of MHCE in vitro and in vivo. In vitro, we evaluated the effects of MHCE on cultured HFDPC, HaCaT cells, and murine embryonal fibroblasts (NIH3T3 cells). Also, we evaluated the ability of MHCE to prevent gray hair on murine melanoma cells (B16F1 cells). The hair growth-promoting effect of MHCE in vitro was also observed in vivo using C57BL/6 mice. Our results showed that MHCE significantly increased the proliferation of HFDPC (175 % proliferation at 50 μg/mL), HaCaT cells (133 % proliferation at 20 μg/mL), and NIH3T3 cells (120 % proliferation at 50 μg/mL). MHCE also showed consistent melanogenesis in B16F1 cells (154 % melanin synthesis at 50 μg/mL). Moreover, MHCE showed potential for hair growth stimulation in C57BL/6 mice experiments (98 % hair growth area on 4 weeks). These results indicate that MHCE may be a good candidate for promotion of hair growth.
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KEYWORD
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medicinal herbal complex extract, hair growth, human follicle dermal papilla cell, NIH3T3 cell, C57BL/6 mice
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